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Feasibility of physiologist-led stress echocardiography for the assessment of coronary artery disease
Echo Research & Practice volume 4, pages 29–36 (2017)
Abstract
Background Physiologist-led stress echocardiography (PLSE) services provide potential for expansion of SE services and increased productivity for cardiologists. There are however no published data on the feasibility of PLSE. We sought to assess the feasibility, safety and robustness of PLSE and cardiologist-led stress echocardiography (CLSE) for coronary artery disease (CAD) assessment.
Methods Retrospective analysis of 898 patients undergoing PLSE or CLSE for CAD assessment using exercise or dobutamine stress over 24 months. PLSE involved 2 cardiac physiologists (exercise) or 1 physiologist plus 1 cardiac nurse (dobutamine). A cardiology registrar was present in the echocardiography department during PLSE in case of medical complications. CLSE involved 1 physiologist and 1 trainee cardiologist who analysed the study and reviewed findings with an imaging cardiologist. Sixteen-segment wall motion scoring (WMS, WMSI) analysis was performed. Feasibility (stressor, image quality, proportion of completed studies, agreement with imaging cardiologist analysis) and safety (complication rate) were compared for PLSE and CLSE.
Results The majority of studies were CLSE (56.2%) and used dobutamine (68.7%). PLSE more commonly used exercise (69.2%). Overall, 96% of studies were successfully completed (>14 diagnostic segments in 98%, P=0.899 PLSE vs CLSE). Commencement of PLSE was associated with an increase in annual SE’s performed for CAD assessment. Complication rates were comparably very low for PLSE and CLSE (0.8% vs 1.8%, P=0.187). There was excellent agreement between PLSE and CLSE WMS interpretation of 480 myocardial segments at rest (κ=0.87) and stress (κ=0.70) and WMSI (ICCs and Pearson’s r >0.90, zero Bland–Altman mean bias).
Conclusion This to our knowledge is the first study of the feasibility of PLSE. PLSE performed by well-trained physiologists is feasible and safe in contemporary practice. PLSE and CLSE interpretation of stress echocardiography for CAD agree very closely.
References
Indrajith M, Garbi M, Monaghan MJ 2016 Setting up a stress echo service: best practice. Heart 102 1763–1770. (doi:10.1136/heartjnl-2015-308165)
Popescu BA, Andrade MJ, Badano LP, Fox KF, Flachskampf FA, Lancellotti P, Varga A, Sicari R, Evangelista A, Nihoyannopoulos P, et al. 2009 European Association of Echocardiography recommendations for training, competence, and quality improvement in echocardiography. European Journal of Echocardiography 10 893–905. (doi:10.1093/ejechocard/jep151)
Sicari R, Nihoyannopoulos P, Evangelista A, Kasprzak J, Lancellotti P, Poldermans D, Voigt JU, Zamorano JL 2009 Stress echocardiography expert consensus statement – executive summary: European Association of Echocardiography (EAE). European Heart Journal 30 278–289. (doi:10.1093/eurheartj/ehn492)
Becher H, Chambers J, Fox K, Jones R, Leech GJ, Masani N, Monaghan M, More R, Nihoyannopoulos P, Rimington H et al. 2004 BSE procedure guidelines for the clinical application of stress echocardiography, recommendations for performance and interpretation of stress echocardiography: a report of the British Society of Echocardiography Policy Committee. Heart 90 (Supplement 6) vi23–vi30. (doi:10.1136/hrt.2004.047985)
Senior R, Monaghan M, Becher H, Mayet J, Nihoyannopoulos P, British Society of Echocardiography 2005 Stress echocardiography for the diagnosis and risk stratification of patients with suspected or known coronary artery disease: a critical appraisal. Supported by the British Society of Echocardiography. Heart 91 427–436. (doi:10.1136/hrt.2004.044396)
Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T & Verani MS 2002 Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 105 539–542. (doi:10.1161/hbib402.102975)
Popp R, Agatston A, Armstrong W, Nanda N, Pearlman A, Rakowski H, Seward J, Silverman N, Smith M, Stewart W et al. 1998 Recommendations for training in performance and interpretation of stress echocardiography. Committee on Physician Training and Education of the American Society of Echocardiography. Journal of the American Society of Echocardiography 11 95–96. (doi:10.1016/S0894-7317(98)70131-2)
Castillo E, Osman NF, Rosen BD, El-Shehaby I, Pan L, Jerosch-Herold M, Lai S, Bluemke DA, Lima JAC 2005 Quantitative assessment of regional myocardial function with MR-tagging in a multi-center study: interobserver and intraobserver agreement of fast strain analysis with Harmonic Phase (HARP) MRI. Journal of Clinical Medicine and Research 7 783–791. (doi:10.1080/10976640500295417)
Viera AJ, Garrett JM 2005 Understanding interobserver agreement: the kappa statistic. Family Medicine 37 360–363.
Bhattacharyya S, Chehab O, Khattar R, Lloyd G, Senior R British Society of Echocardiography 2014 Stress echocardiography in clinical practice: a United Kingdom National Health Service Survey on behalf of the British Society of Echocardiography. European Heart Journal: Cardiovascular Imaging 15 158–163. (doi:10.1093/ehjci/jebib82)
Varga A, Garcia MA, Picano E International Stress Echo Complication Registry 2006 Safety of stress echocardiography (from the International Stress Echo Complication Registry). American Journal of Cardiology 98 541–543. (doi:10.1016/j.amjcard.2006.02.064)
Geleijnse ML, Krenning BJ, Nemes A, van Dalen BM, Soliman OI, Ten Cate FJ, Schinkel AF, Boersma E, Simoons ML 2010 Incidence, pathophysiology, and treatment of complications during dobutamine-atropine stress echocardiography. Circulation 121 1756–1767. (doi:10.1161/CIRCULATIONAHA.109.859264)
BCS 2015 Strategic Review of Cardiac Physiology Services in England: Final Report. London, UK:, British Cardiovascular Society. (available at: http://www.bcs.com/documents/SRCPS_Final_Report_12052015_2.pdf)
Chambers J, Lloyd G, Rimington HM, Parkin D, Hayes AM, Baldrock-Apps G, Topham A 2011 Multidisciplinary valve clinics with devolved surveillance: a two-year audit. British Journal of Cardiology 18 231–232. (doi:10.5837/bjc.2011.004)
DOH 2010 Modernising Scientic Careers: The England Action Plan. London, UK: Department of Health. (available at: https://www.gov.uk/government/publications/modernising-scientific-careers-the-england-action-plan)
Shah BN, Senior R 2016 Stress echocardiography in patients with morbid obesity. Echo Research and Practice 3 R13–R18. (doi:10.1530/ERP-16-0010)
Allen BD, Chatterjee N, Ayache J, Freed BH, Lee DC, Carroll T, Markl M, Collins JD, Carr JC 2015 Stress perfusion cardiac MRI with regadenoson and gadofoveset trisodium. Journal of Clinical Medicine and Research 17 P113. (doi:10.1186/1532-429x-17-s1-p113)
Duvall WL, Croft LB, Corriel JS, Einstein AJ, Fisher JE, Haynes PS, Rose RK, Henzlova MJ 2006 SPECT myocardial perfusion imaging in morbidly obese patients: image quality, hemodynamic response to pharmacologic stress, and diagnostic and prognostic value. Journal of Nuclear Cardiology 13 202–209. (doi:10.1007/BF02971244)
Picano E, Lattanzi F, Orlandini A, Marini C, L’Abbate A 1991 Stress echocardiography and the human factor: the importance of being expert. Journal of the American College of Cardiology 17 666–669. (doi:10.1016/S0735-1097(10)80182-2)
Soman P, Lahiri A, Senior R 2004 Vasodilator stress induces infrequent wall thickening abnormalities compared to perfusion defects in mild-to-moderate coronary artery disease: implications for the choice of imaging modality with vasodilator stress. Echocardiography 21 307–312. (doi:10.1111/j.0742-2822.2004.03006.x)
Picano E, Lattanzi F, Masini M, Distante A, L’Abbate A 1987 Comparison of the high-dose dipyridamole-echocardiography test and exercise two-dimensional echocardiography for diagnosis of coronary artery disease. American Journal of Cardiology 59 539–542. (doi:10.1016/0002-9149(87)91165-9)
Varga A, Picano E, Dodi C, Barbieri A, Pratali L, Gaddi O 1999 Madness and method in stress echo reading. European Heart Journal 20 1271–1275. (doi:10.1053/euhj.1999.1541)
Mertes H, Sawada SG, Ryan T, Segar DS, Kovacs R, Foltz J, Feigenbaum H 1993 Symptoms, adverse effects, and complications associated with dobutamine stress echocardiography. Experience in 1118 patients. Circulation 88 15–19. (doi:10.1161/01.CIR.88.1.15)
Pellikka PA, Roger VL, Oh JK, Miller FA, Seward JB, Tajik AJ 1995 Stress echocardiography. Part II. Dobutamine stress echocardiography: techniques, implementation, clinical applications, and correlations. Mayo Clinic Proceedings 70 16–27. (doi:10.1016/S0025-6196(11)64660-0)
Zahn R, Lotter R, Nohl H, Schiele R, Bergmeier C, Zander M, Seidl K & Senges J 1996 Feasibility and safety of dobutamine stress echocardiography: experiences with 1,000 studies. Zeitschrift füdiologie 85 28–34.
Elhendy A, van Domburg RT, Poldermans D, Bax JJ, Nierop PR, Geleijnse ML, Roelandt JR 1998 Safety and feasibility of dobutamine-atropine stress echocardiography for the diagnosis of coronary artery disease in diabetic patients unable to perform an exercise stress test. Diabetes Care 21 1797–1802. (doi:10.2337/diacare.21.11.1797)
Bremer ML, Monahan KH, Stussy VL, Miller FA, Seward JB, Pellikka PA 1998 Safety of dobutamine stress echocardiography supervised by registered nurse sonographers. Journal of the American Society of Echocardiography 11 601–605. (doi:10.1016/S0894-7317(98)70035-5)
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Khan, J.N., Griffiths, T., Fatima, T. et al. Feasibility of physiologist-led stress echocardiography for the assessment of coronary artery disease. Echo Res Pract 4, 29–36 (2017). https://doiorg.publicaciones.saludcastillayleon.es/10.1530/ERP-17-0019
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DOI: https://doiorg.publicaciones.saludcastillayleon.es/10.1530/ERP-17-0019