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Echocardiographic global longitudinal strain is associated with infarct size assessed by cardiac magnetic resonance in acute myocardial infarction

Echo Research & Practice volume 6, pages 81–89 (2019)Cite this article

Abstract

The aim of this study was to investigate if there was an association between infarct size (IS) measured by cardiac magnetic resonance (CMR) and echocardiographic global longitudinal strain (GLS) in the early stage of acute myocardial infarction in patients with preserved left ventricular ejection fraction (LVEF). Patients with ST-segment elevation myocardial infarction who underwent primary percutaneous coronary intervention were assessed with CMR and transthoracic echocardiogram within 1 week of hospital admission. Two-dimensional speckle tracking was performed using a semi-automatic algorithm (EchoPac, GE Healthcare). Longitudinal strain curves were generated in a 17-segment model covering the entire left ventricular myocardium. GLS was calculated automatically. LVEF was measured by auto-LVEF in EchoPac. IS was measured by late gadolinium enhancement CMR in short-axis views covering the left ventricle. The study population consisted of 49 patients (age 60.4 ± 9.7 years; 92% male). The study population had preserved echocardiographic LVEF with a mean of 45.8 ± 8.7%. For each percent increase of IS, we found an impairment in GLS by 1.59% (95% CI 0.57–2.61), P = 0.02, after adjustment for sex, age and LVEF. No significant association between IS and echocardiographic LVEF was found: −0.25 (95% CI: −0.61 to 0.11), P = 0.51. At the segmental level, the strongest association between IS and longitudinal strain was found in the apical part of the LV: impairment of 1.69% (95% CI: 1.14–2.23), P < 0.001, for each percent increase in IS. In conclusion, GLS was significantly associated with IS in the early stage of acute myocardial infarction in patients with preserved LVEF, and this association was strongest in the apical part of the LV. No association between IS and LVEF was found.

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Funding

The region of postgraduate medical education administration office, Viborg, Denmark.

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Authors and Affiliations

  1. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

    Gowsini Joseph MD, Svend Eggert Jensen MD PhD & Peter Sogaard MD DMSc

  2. Department of Cardiology, North Denmark Regional Hospital, Hjorring, Denmark

    Gowsini Joseph MD & Svend Eggert Jensen MD PhD

  3. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark

    Gowsini Joseph MD, Tomas Zaremba MD PhD & Peter Sogaard MD DMSc

  4. Unit of Clinical Biostatistics, Aalborg University Hospital, Aalborg, Denmark

    Martin Berg Johansen

  5. Department of Cardiology, Nephrology and Endocrinology, North Zealand Hospital, Hillerod, Denmark

    Sarah Ekeloef MD PhD

  6. Department of Clinical Physiology, Lund University and Skaane University Hospital, Lund, Sweden

    Einar Heiberg MSc PhD & Henrik Engblom MD PhD

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Correspondence to Gowsini Joseph MD.

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Joseph, G., Zaremba, T., Johansen, M.B. et al. Echocardiographic global longitudinal strain is associated with infarct size assessed by cardiac magnetic resonance in acute myocardial infarction. Echo Res Pract 6, 81–89 (2019). https://doiorg.publicaciones.saludcastillayleon.es/10.1530/ERP-19-0026

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Echo Research & Practice

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